BETd-246

• Description :

  BETd-246 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity[1].

• CAS Number :

  [2140289-17-2]

• Product Name Alternative :

  CP21

• UNSPSC :

  12352005

• Target :

  Epigenetic Reader Domain; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; PROTAC

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/BETd-246.html

• Purity :

  98.34

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NC(NC2=CC(C3CC3)=NN2CC)=C4C(NC5=C4C=C(OC)C(C6=C(C)ON=C6C)=C5)=N1)NCCCOCCOCCOCCCNC7=CC=CC(C(N8C(CC9)C(NC9=O)=O)=O)=C7C8=O

• Molecular Formula :

  C48H55N11O10

• Molecular Weight :

  946.02

• References & Citations :

  [1]Bai L, et al. Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer. Cancer Res. 2017 May 1;77 (9) :2476-2487.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported