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Factor IX Polyclonal Antibody

CAT: 0749-ABP57530-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57530-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
F9 (coagulation factor IX) encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of F9, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
Description
Rabbit Anti-Factor IX Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC
Gene ID
2158
Accession Number
P00740
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from Factor IX at AA range: 412-461
Clonality
Polyclonal
Tag
Factor IX
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
52kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Factor IX Polyclonal Antibody detects endogenous levels of Factor IX.
Observed Molecular Weight
52
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:10000-20000
Other Product Names
Coagulation factor IX; Christmas factor; Plasma thromboplastin component; PTC
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P00740
Isotype
Rabbit IgG

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