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Factor VIII Polyclonal Antibody

CAT: 0749-ABP51315-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51315-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. F8 produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. DefectsF8 results in hemophilia A, a common recessive X-linked coagulation disorder.
Description
Rabbit Anti-Factor VIII Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component
Gene ID
2157
Accession Number
P00451
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the C-terminal region of human Factor VIII at AA range: 2130-2210
Clonality
Polyclonal
Tag
Coagulation factor VIII
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
300kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Factor VIII Polyclonal Antibody detects endogenous levels of Factor VIII protein.
Observed Molecular Weight
300
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Other Product Names
F8; F8C; Coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P00451
Isotype
Rabbit IgG

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