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Factor H Antibody (Polyclonal)

CAT: 1008-A312Size: 2.0 mLDry Ice: NoHazardous: No
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CAT#:1008-A312Size:2.0 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Factor H is a single-chain glycoprotein with a molecular weight of approximately 150 KD. The concentration of this protein in normal human plasma/serum is approximately 500 μg/mL. Factor H can regulate the complement system on both the cellular surface and in fluid phase, and plays roles in both the alternative and classical pathways of activation. Factor H regulates formation and function of C3 convertase enzyme in the alternative pathway. It binds to C3b and inhibits C3 convertase formation, dissociates assembled C3 convertase, accelerates Factor I mediated cleavage of C3b to C3bi, and hinders C5 binding to the C3b subcomponent of both the alternative and classical pathways. Factor H also regulates the spontaneous fluid-phase activation of the alternative complement pathway by C3b-like forms of C3 that continuously arise in plasma and serum. Therefore, when concentrations of Factor H fall below normal levels, rapid fluid-phase activation occurs which causes consumption of complement components both in vivo and in vitro.
Description
A goat antiserum raised against human Factor H.
Cross Reactivity
Human, Baboon, Horse, Dog, Cat, Rabbit, Hamster, Mouse, Rat, Guinea Pig
Immunogen
Highly purified human Factor H
Clonality
Polyclonal
Source
Goat
Applications
See citations and technical data sheet for application info.
Concentration
> 40 mg/mL
Form
Liquid. Whole Antiserum. ≤ 0.1% Sodium Azide
Storage Conditions
Short term (30 days) 4 ̊C. Long term at or below –20 ̊C.
Specificity
The Anti-human Factor H polyclonal antisera was tested against normal human serum/plasma by immunodiffusion, one-dimensional immunoelectrophoresis, and rocket immunoelectrophoresis. The antisera was determined to be monospecific for Factor H at varying concentrations.
Isotype
Goat IgG
Conjugate
Unconjugated

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