Factor I Polyclonal Antibody

• Background :

  CFI encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

• Description :

  Rabbit Anti-Factor I Polyclonal Antibody

• Product Name Alternative :

  CFI; IF; Complement factor I; C3B/C4B inactivator

• Gene ID :

  3426

• Accession Number :

  P05156

• Reactivity :

  Human, Rat, Mouse

• Immunogen :

  Synthesized peptide derived from the Internal region of human Factor I at AA rangle: 410-490

• Clonality :

  Polyclonal

• Tag :

  Complement factor I

• Applications :

  WB, ELISA

• Purification Method :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration :

  1 mg/ml

• Molecular Weight :

  Full lenth:66kD, heavy chain:50-58kD

• Precautions :

  The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

• Shipping Conditions :

  Gel pack with blue ice.

• Storage Conditions :

  Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

• Notes :

  Factor I Polyclonal Antibody detects endogenous levels of Factor I protein.

• Observed Molecular Weight :

  66

• Formulation :

  Liquid solution

• Buffer pH :

  Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applications Notes :

  Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; ELISA 1:10000; Not yet tested in other applications.

• Other Product Names :

  CFI; IF; Complement factor I; C3B/C4B inactivator

• Tested Applications :

  WB, IHC, IF, IP, ELISA

• Host or Source :

  Rabbit

• Accession Number URL :

  http://www.uniprot.org/uniprot/P05156

• CAS Number :

  9007-83-4

• Isotype :

  Rabbit IgG