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FAT10 Polyclonal Antibody

CAT: 0749-ABP57367-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP57367-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for FAT10 conjugate formation. FAT10 is inducible by interferon-g and tumor necrosis factor a (TNF) . The FAT10 protein interacts with MAD2, a component of the spindle checkpoint, and plays a role in antigen presentation, cytokine response, apoptosis and mitosis. It may also regulate cell growth during dendritic cell or B cell activation and development. FAT10 mRNA is expressed mainly in some dendritic cells and lymphoblastoid lines and in other specific cells subsequent to interferon-g induction. The human FAT10 gene, designated UBD, maps to chromosome 6p21. and is overexpressed in the tumors of various epithelial cancers.
Description
Rabbit Anti-FAT10 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
UBD; FAT10; Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10
Accession Number
O15205
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from the Internal region of human FAT10
Clonality
Polyclonal
Tag
Ubiquitin D
Applications
WB, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
18kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
FAT10 Polyclonal Antibody detects endogenous levels of FAT10 protein.
Observed Molecular Weight
18
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Other Product Names
UBD; FAT10; Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O15205
Isotype
Rabbit IgG

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