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FAT10 Polyclonal Antibody

CAT: 0965-JOT-AP03172-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP03172-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for FAT10 conjugate formation. FAT10 is inducible by interferon-g and tumor necrosis factor a (TNF). The FAT10 protein interacts with MAD2, a component of the spindle checkpoint, and plays a role in antigen presentation, cytokine response, apoptosis and mitosis. It may also regulate cell growth during dendritic cell or B cell activation and development. FAT10 mRNA is expressed mainly in some dendritic cells and lymphoblastoid lines and in other specific cells subsequent to interferon-g induction. The human FAT10 gene, designated UBD, maps to chromosome 6p21. and is overexpressed in the tumors of various epithelial cancers.
CAS Number
9007-83-4
Synonyms
UBD; FAT10; Ubiquitin D; Diubiquitin; Ubiquitin-like protein FAT10
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of human FAT10.
Clonality
Polyclonal
Applications
WB, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
18457
Antibody Type
Primary antibody
Isotype
IgG

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