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H3C1 Polyclonal Antibody

CAT: 0763-D-AB-10286L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10286L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones are small, highly basic proteins that consist of a globular domain with unstructured N- and C-terminal tails protruding from the main structure. Histone H3 is one of the five main histones that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. In addition to their role in DNA compartmentalization, histones also play crucial roles in various biologic processes, including gene expression and regulation, DNA repair, chromatin condensation, cell cycle progression, chromosome segregation, and apoptosis. The ability of histones to regulate chromatin dynamics primarily originates from various posttranslational modifications carried out by histone-modifying enzymes.
Abbreviation
H3C1
UniProt
P68431
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant Human H3C1 protein expressed by E.coli
Target
H3/A; H3FA; H3FB; H3FC; H3FD; H3FF; H3FH; H3FI; H3FJ; H3FK; H3FL; HIST1H3A; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; histone cluster 1; H3a; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Epigenetics and Nuclear Signaling
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
15kDa
Observed Molecular Weight
15kDa
Isotype
IgG

UniProtKB · P68431

Histone H3.1

H31_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P68431
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
H3C1, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3C10, H3C11, H3C12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0PJT7, A5PLR1, P02295, P02296, P16106, Q6ISV8, Q6NWP8, Q6NWP9, Q6NXU4, Q71DJ3, Q93081
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationADP-ribosylationCitrullinationHydroxylationIsopeptide bondLipoproteinMethylationPhosphoproteinUbl conjugation

Cellular component

ChromosomeNucleosome coreNucleus

Disease

Disease variant

Molecular function

DNA-binding

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