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UCHL1 Polyclonal Antibody

CAT: 0763-D-AB-10171L-01Size: 25 µLDry Ice: NoHazardous: No
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CAT#:0763-D-AB-10171L-01Size:25 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable) . This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.Also binds to free monoubiquitin and may prevent its degradation in lysosomes.The homodimer may have ATP-independent ubiquitin ligase activity
Abbreviation
UCHL1
UniProt
P09936
Host
Rabbit
Reactivity
Human; Rat
Immunogen
Recombinant Human UCHL1 protein expressed by E.coli
Target
UCHL1; UCH-L1; EC:3.4.19.12; Ubiquitin carboxyl-terminal hydrolase isozyme L1; Neuron cytoplasmic protein 9.5; PGP 9.5 (PGP9.5) ; Ubiquitin thioesterase L1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Cell Biology; Neuroscience; Tags and Cell Markers
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
25 kDa
Observed Molecular Weight
27 kDa
Isotype
IgG

UniProtKB · P09936

Ubiquitin carboxyl-terminal hydrolase isozyme L1

UCHL1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P09936
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
UCHL1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
UCH-L1
EC number
3.4.19.12
Processing
Precursor
Secondary accessions
Q4W5K6, Q71UM0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationGlycoproteinLipoproteinOxidationPhosphoproteinPrenylation

Coding sequence diversity

Alternative initiation

Cellular component

CytoplasmEndoplasmic reticulumMembrane

Disease

Disease variantHereditary spastic paraplegiaNeurodegenerationParkinson diseaseParkinsonism

Molecular function

HydrolaseProteaseThiol protease

Biological process

Ubl conjugation pathway

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