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Stat5a (phospho Ser780) Polyclonal Antibody

CAT: 0749-ABP56300-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56300-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by STAT5A (signal transducer and activator of transcription 5A) is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of STAT5A is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for STAT5A.
Description
Rabbit Anti-Stat5a (phospho Ser780) Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
STAT5A; STAT5; Signal transducer and activator of transcription 5A
Gene ID
6776
Accession Number
P42229
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Stat5a around the phosphorylation site of S780
Clonality
Polyclonal
Tag
Signal transducer and activator of transcription 5A
Applications
WB, IHC, IF, IP, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
91kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Phospho-Stat5a (S780) Polyclonal Antibody detects endogenous levels of Stat5a protein only when phosphorylated at S780.
Observed Molecular Weight
91
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IP 2-5 ug:mg lysate; ELISA 1:10000; IF 1:50-200
Other Product Names
STAT5A; STAT5; Signal transducer and activator of transcription 5A
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P42229
Isotype
Rabbit IgG

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