Stat5a Polyclonal Antibody

CAT: 0749-ABP52518-01Size: 30 µLDry Ice: NoHazardous: No
CAT#:0749-ABP52518-01Size:30 µL
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Background
Stat5 is activated in response to a wide variety of ligands including IL-2, GM-CSF, growth hormone and prolactin. Phosphorylation at Tyr694 is obligatory for Stat5 activation. This phosphorylation is mediated by Src upon erythropoietin stimulation. Stat5 is constitutively active in some leukemic cell types. Phosphorylated Stat5 is found in some endothelial cells treated with IL-3, which suggests its involvement in angiogenesis and cell motility. Stat5a and Stat5b are independently regulated and activated in various cell types. For instance, interferon treatment predominantly activates Stat5a in U-937 cells and Stat5b in HeLa cells.
Description
Rabbit Anti-Stat5a Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
STAT5A; STAT5; Signal transducer and activator of transcription 5A
Gene ID
6776
Accession Number
P42229
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from human Stat5a around the non-phosphorylation site of S780
Clonality
Polyclonal
Tag
Signal transducer and activator of transcription 5A
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
91kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Stat5a Polyclonal Antibody detects endogenous levels of Stat5a protein.
Observed Molecular Weight
91
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
STAT5A; STAT5; Signal transducer and activator of transcription 5A
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P42229
Isotype
Rabbit IgG

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