FGFR-3 Polyclonal Antibody

FGFR3 encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Rabbit Anti-FGFR-3 Polyclonal Antibody

9007-83-4

FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333

2261

P22607

Human, Mouse, Rat

Synthesized peptide derived from the Internal region of human FGFR-3 at AA rangle: 100-180

Fibroblast growth factor receptor 3

WB, IHC, IF, ELISA

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

95-130kD

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Gel pack with blue ice.

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

FGFR-3 Polyclonal Antibody detects endogenous levels of FGFR-3 protein.

95

Liquid solution

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200

FGFR3; JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD antigen CD333

WB, IHC, IF, IP, ELISA

Rabbit

http://www.uniprot.org/uniprot/P22607