FGFR-3 neutralizing antibody

• Description:

  Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfateproteoglycans as cofactors. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms. The IIIb or IIIc isoforms recognize FGF1, 2, 4, 8b, 8e, 8f, 9, and 17b. FGF R3 plays a role in skeletal, brain, lung, intestine, kidney, and skin development.

• Synonyms:

  FGFR3; ACH; CEK2; JTK4; CD333; HSFGFR3EX

• NCBI Gene ID:

  2261

• UniProt:

  P22607

• Accession Number:

  NP_000133

• Accession Number mRNA:

  NM_000142

• Chromosomal Location:

  4p16.3

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Highly purified human sFGFR-3

• Clone:

  Recombinant IG

• Purification Method:

  Ion exchange chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  Water

• Storage Conditions:

  Lyophilized samples are stable for up to a year at -20°C. Upon reconstitution, the Fab is stable for up to 1 month at 4°C or up to 1 year at -20°C.

• Host or Source:

  E. coli

• Isotype:

  Fab-Fragment