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Coelenteramine 400a

CAT: 0804-HY-118462-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-118462-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm[1][2]. Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) [3].
CAS Number
70217-82-2
Product Name Alternative
Coelenterazine 400a; Bisdeoxycoelenterazine
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/coelenteramine-400a.html
Purity
99.70
Solubility
DMSO : 8.33 mg/mL (ultrasonic) |Ethanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C(CC2=CC=CC=C2)=NC3=C(NC(C4=CC=CC=C4)=CN31)CC5=CC=CC=C5
Molecular Formula
C26H21N3O
Molecular Weight
391.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Levi J, et, al. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. J Am Chem Soc. 2007 Oct 3;129 (39) :11900-1. |[2]Bertrand L, et, al. The BRET2/arrestin assay in stable recombinant cells: a platform to screen for compounds that interact with G protein-coupled receptors (GPCRS) . J Recept Signal Transduct Res. Feb-Nov 2002;22 (1-4) :533-41.|[3]Yuan M L, et al. Luminescence of coelenterazine derivatives with C-8 extended electronic conjugation[J]. Chinese Chemical Letters, 2016, 27 (4) : 550-554.|[4]Ikeda Y, et al. Quantitative evaluation of luminescence intensity from enzymatic luminescence reaction of coelenterazine and analogues. Journal of Photochemistry and Photobiology A: Chemistry, 2020, 394: 112459.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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