Eras-4001

• Description :

  Eras-4001 (Compound 14-1) is a pan-KRAS inhibitor. Eras-4001 has potent antitumor activities and significantly inhibits the proliferation of wild-type and mutant (such as KRASG12D, KRASG12V and KRASG12C) cancer cells. Eras-4001 effectively inhibits tumor growth in GP2D and Panc0403 xenograft mouse models[1].

• UNSPSC :

  12352005

• Target :

  Ras

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  FC1=C([C@@H]2CC(N=C(OC[C@@]34CCCN3CC(C4)=C)N=C5N6CC7=C(Cl)C(C(N(C)C)=O)=NN7CCC6)=C5CO2)C(C(F)(F)F)=C(C#CC)C=C1N

• Molecular Formula :

  C36H39ClF4N8O3

• Molecular Weight :

  743.19

• References & Citations :

  [1]Zhang Y, et al. Heterocyclic substituted pyrimidopyran compound and use thereof. WO2023246914A1. 2023-12-28.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [3024878-19-8]