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Coelenterazine h

CAT: 0804-HY-D1024-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D1024-01Size:1 mg
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Description
Coelenterazine h (2-Deoxycoelenterazine), a coelenterazine derivative, is a luminescent substrate for RLuc8. Coelenterazine h is more sensitive to Ca2+, thus providing a valuable tool for measuring small changes in Ca2+ concentrations (Ex/Em = 437/466 nm) [1][2][3][4].
CAS Number
50909-86-9
Product Name Alternative
2-Deoxycoelenterazine; CLZN-h
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Dye Reagents
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Coelenterazine_h.html
Purity
99.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C2=CN(C(C(CC3=CC=CC=C3)=N4)=O)C4=C(N2)CC5=CC=CC=C5
Molecular Formula
C26H21N3O2
Molecular Weight
407.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Jiang T, et al. New bioluminescent coelenterazine derivatives with various C-6 substitutions. Org Biomol Chem. 2017 Aug 23;15 (33) :7008-7018.|[2]M R Knight, et al. Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins. J Cell Biol. 1993 Apr;121 (1) :83-90. |[3]Kazushi Suzuki, et al. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun. 2016 Dec 14:7:13718. |[4]Kenta Saito, et al. Auto-luminescent genetically-encoded ratiometric indicator for real-time Ca2+ imaging at the single cell level. PLoS One. 2010 Apr 1;5 (4) :e9935.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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