Products for Research Use Only
RegisterLogin

Alectinib (Standard)

CAT: 0804-HY-13011R-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-13011R-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Alectinib (Standard) is the analytical standard of Alectinib. This product is intended for research and analytical applications. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
CAS Number
1256580-46-7
Product Name Alternative
CH5424802 (Standard) ; RO5424802 (Standard) ; RG7853 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Anaplastic lymphoma kinase (ALK) ; Reference Standards
Type
Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alectinib-standard.html
Purity
99.60
Smiles
N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1
Molecular Formula
C30H34N4O2
Molecular Weight
482.62
Precautions
H302, H315, H319, H335
References & Citations
[1]Sakamoto H, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011, 19 (5), 679-690.|[2]Gadgeel S, et al. Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study. Ann Oncol. 2018 Nov 1;29 (11) :2214-2222.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

Related Products

CatalogName
HY-13011AR-01Alectinib (Hydrochloride) (Standard)
HY-77093RAlectinib impurity 1 (Standard)
HY-13011-01Alectinib
HY-13011SAlectinib-d8
HY-13011S1Alectinib-d6
HY-13011A-01Alectinib (Hydrochloride)
HY-W814315-01Alectinib analog
HY-77093-01Alectinib impurity 1
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)

Alternative Products

CatalogName
abx183840-01Alectinib
A4649-25Alectinib Hydrochloride
TMID-0073-01Alectinib-d8
ENZ-CHM213-0200Alectinib . hydrochloride

Popular Products