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Crk II Polyclonal Antibody

CAT: 0749-ABP51053-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP51053-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CRK encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of CRK has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Description
Rabbit Anti-Crk II Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
Gene ID
1398
Accession Number
P46108
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthesized peptide derived from human Crk II around the non-phosphorylation site of Y221
Clonality
Polyclonal
Tag
Adapter molecule crk
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
40kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Crk II Polyclonal Antibody detects endogenous levels of Crk II protein.
Observed Molecular Weight
40
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications.
Other Product Names
CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P46108
Isotype
Rabbit IgG

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