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Topo IIβ Polyclonal Antibody

CAT: 0749-ABP56420-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP56420-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TOP2B (topoisomerase (DNA) II beta) encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. TOP2B encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in TOP2B have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of TOP2B results in two transcript variants; however, the second variant has not yet been fully described.
Description
Rabbit Anti-Topo IIβ Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme
Gene ID
7155
Accession Number
Q02880
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from the N-terminal region of human Topo IIβ at AA range: 10-90
Clonality
Polyclonal
Tag
DNA topoisomerase 2-beta
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
183kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Topo IIβ Polyclonal Antibody detects endogenous levels of Topo IIβ protein.
Observed Molecular Weight
183
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
TOP2B; DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q02880
Isotype
Rabbit IgG

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