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BIRC2 rabbit pAb

CAT: 0855-ES11955-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11955-02Size:100 µL
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Background
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Description
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
UniProt
Q13490
Swiss Prot
Q13490
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
67kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
67kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
Gene ID (Human)
329

UniProtKB · Q13490

Baculoviral IAP repeat-containing protein 2

BIRC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13490
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BIRC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
B4E026, Q16516, Q4TTG0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorTransferase

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulationUbl conjugation pathway

Cellular component

CytoplasmNucleus

Ligand

Metal-bindingZinc

Domain

RepeatZinc-finger

PTM

Ubl conjugation

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