SCRIB rabbit pAb
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SCRIB rabbit pAb
Background:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011]Description:
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2011],UniProt:
Q14160Swiss Prot:
Q14160Reactivity:
Human; Rat; MouseImmunogen:
Synthesized peptide derived from part region of human proteinClonality:
PolyclonalSource:
RabbitApplications:
WB; ELISAConcentration:
1 mg/mlDilution:
WB 1:500-2000 ELISA 1:5000-20000Molecular Weight:
179kDStorage Conditions:
-20°C/1 yearObserved Molecular Weight:
179kDFragment:
IgGSubcellular Location:
Cell membrane ; Peripheral membrane protein. Cell junction . Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (By similarity) . .Gene ID (Human):
23513