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TIAM1 rabbit pAb

CAT: 0855-ES11819-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11819-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA., similarity:Belongs to the TIAM family., similarity:Contains 1 DH (DBL-homology) domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 PH domain., similarity:Contains 1 RBD (Ras-binding) domain., similarity:Contains 2 PH domains., subunit:Interacts with BAIAP2., tissue specificity:Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
Description
Function: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. similarity: Belongs to the TIAM family. similarity: Contains 1 DH (DBL-homology) domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 PH domain. similarity: Contains 1 RBD (Ras-binding) domain. similarity: Contains 2 PH domains. subunit: Interacts with BAIAP2. tissue specificity: Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
UniProt
Q13009
Swiss Prot
Q13009
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
175kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
175kD
Fragment
IgG
Subcellular Location
Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the boundary between cells with actin-rich protrusions (By similarity) . Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. .
Gene ID (Human)
7074

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