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APTX rabbit pAb

CAT: 0855-ES11441-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11441-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Aprataxin (APTX) Homo sapiens This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]
Description
Aprataxin (APTX) Homo sapiens This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],
UniProt
Q7Z2E3
Swiss Prot
Q7Z2E3
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 11-60
Target
APTX
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
39kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
39kD
Fragment
IgG
Subcellular Location
Nucleus, nucleoplasm . Nucleus, nucleolus . Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage (PubMed:15380105) . Colocalizes with MDC1 at sites of DNA double-strand breaks (PubMed:20008512) . Interaction with NCL is required for nucleolar localization (PubMed:16777843) . .; [Isoform 12]: Cytoplasm .
Gene ID (Human)
54840