APTX rabbit pAb

• Background :

  Aprataxin (APTX) Homo sapiens This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]

• Description :

  Aprataxin (APTX) Homo sapiens This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],

• UniProt :

  Q7Z2E3

• Swiss Prot :

  Q7Z2E3

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 11-60

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  39kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  39kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, nucleoplasm . Nucleus, nucleolus . Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage (PubMed:15380105) . Colocalizes with MDC1 at sites of DNA double-strand breaks (PubMed:20008512) . Interaction with NCL is required for nucleolar localization (PubMed:16777843) . .; [Isoform 12]: Cytoplasm .

• Gene ID (Human) :

  54840