SARM1 rabbit pAb

SARM1 rabbit pAb

• Description: Caution: Was initially reported to contain ARM repeats (PubMed: 11386760). Such repeats are however not predicted by any detection method. function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. similarity: Contains 1 TIR domain. similarity: Contains 2 SAM (sterile alpha motif) domains. subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. tissue specificity: Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
• Gene ID: 23098
• UniProt: Q6SZW1
• Cellular Locus: Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Associated with microtubules..
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthesized peptide derived from human protein . at AA range: 281-330
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 79kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.