SARM1 rabbit pAb

• Background:

  Caution:Was initially reported to contain ARM repeats (PubMed:11386760) . Such repeats are however not predicted by any detection method., function:Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation., similarity:Contains 1 TIR domain., similarity:Contains 2 SAM (sterile alpha motif) domains., subunit:Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function., tissue specificity:Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

• Description:

  Caution: Was initially reported to contain ARM repeats (PubMed: 11386760). Such repeats are however not predicted by any detection method. function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation. similarity: Contains 1 TIR domain. similarity: Contains 2 SAM (sterile alpha motif) domains. subunit: Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function. tissue specificity: Predominantly expressed in kidney and liver. Expressed at lower level in placenta.

• Gene ID:

  23098

• UniProt:

  Q6SZW1

• Cellular Locus:

  Cytoplasm. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Mitochondrion. Associated with microtubules..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse

• Reactivity:

  Human; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 281-330

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  79kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  79 kD

• Subcellular Location:

  Cytoplasm . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse . Mitochondrion . Associated with microtubules. .

• Gene ID (Human):

  23098

• SwissProt (Human):

  Q6SZW1