AMGO2 rabbit pAb

AMGO2 rabbit pAb

• Background :

  Function:Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas., similarity:Belongs to the immunoglobulin superfamily. AMIGO family., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 6 LRR (leucine-rich) repeats., subcellular location:Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons., subunit:Binds itself as well as AMIGO1 and AMIGO3., tissue specificity:Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

• Description :

  Function: Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas. similarity: Belongs to the immunoglobulin superfamily. AMIGO family. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 6 LRR (leucine-rich) repeats. subcellular location: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons. subunit: Binds itself as well as AMIGO1 and AMIGO3. tissue specificity: Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.

• UniProt :

  Q86SJ2

• Swiss Prot :

  Q86SJ2

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 270-350

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  57kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  57kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein . Nucleus . Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons (By similarity) . .

• Gene ID (Human) :

  347902