LAX1 rabbit pAb

• Background:

  Function:Negatively regulates TCR (T-cell antigen receptor) -mediated signaling in T-cells and BCR (B-cell antigen receptor) -mediated signaling in B-cells., induction:Up-regulated in T-cells following TCR engagement., PTM:Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2., subunit:When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2., tissue specificity:Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.

• Description:

  Function: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells. induction: Up-regulated in T-cells following TCR engagement. PTM: Phosphorylated on tyrosines by Syk, Lck or ZAP70 upon TCR or BCR activation; which leads to the recruitment of GRB2, PIK3R1 and GRAP2. subunit: When phosphorylated, interacts with GRB2, PIK3R1 and GRAP2. tissue specificity: Expressed in spleen, thymus, and peripheral blood leukocytes. Expressed in several B-, T-, NK and monocyte cell lines.

• UniProt:

  Q8IWV1

• Swiss Prot:

  Q8IWV1

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 30-110

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  43kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  43kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane ; Single-pass type III membrane protein .

• Gene ID (Human):

  54900