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GBLP rabbit pAb

CAT: 0855-ES11069-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11069-01Size:50 µL
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Background
Domain:The WD repeats domain 5 mediates interaction with TRIM63., function:Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation., similarity:Belongs to the WD repeat G protein beta family., similarity:Contains 7 WD repeats., subcellular location:Located on plasma membrane of neuroblastoma NMB7 cells., subunit:Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.
Description
Domain: The WD repeats domain 5 mediates interaction with TRIM63. function: Seems to bind protein kinase C acting as an intracellular receptor to anchor the activated PKC to the cytoskeleton. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and ITGB1, serves as a platform for SRC activation or inactivation. May play an important role in the developing brain and neuronal differentiation. similarity: Belongs to the WD repeat G protein beta family. similarity: Contains 7 WD repeats. subcellular location: Located on plasma membrane of neuroblastoma NMB7 cells. subunit: Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4 and KRT1.
UniProt
P63244
Swiss Prot
P63244
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
GBLP
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
34kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
34kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein. Cytoplasm . Cytoplasm, perinuclear region . Nucleus . Perikaryon . Cell projection, dendrite . Cell projection, phagocytic cup . Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333) . Also associated with the membrane in oncogene-transformed cells (PubMed:11884618) . PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199) . In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity) . Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310) . .
Gene ID (Human)
10399

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