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KLOTB rabbit pAb

CAT: 0855-ES11020-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11020-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive., function:Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21., similarity:Belongs to the glycosyl hydrolase 1 family., similarity:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily., subunit:Interacts with FGFR1 and FGFR4.
Description
Domain: Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive. function: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. similarity: Belongs to the glycosyl hydrolase 1 family. similarity: Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. subunit: Interacts with FGFR1 and FGFR4.
UniProt
Q86Z14
Swiss Prot
Q86Z14
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
114kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
114kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type III membrane protein .
Gene ID (Human)
152831

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