SIGIR rabbit pAb

SIGIR rabbit pAb

• Description: Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. similarity: Belongs to the interleukin-1 receptor family. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 1 TIR domain. subunit: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.
• Gene ID: 59307
• UniProt: Q6IA17
• Cellular Locus: Membrane ; Single-pass type III membrane protein.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthesized peptide derived from part region of human protein
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 45kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.