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SIGIR rabbit pAb

CAT: 0855-ES10876-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10876-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP., similarity:Belongs to the interleukin-1 receptor family., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 TIR domain., subunit:Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6., tissue specificity:Mainly expressed in epithelial tissues such as kidney, lung and gut.
Description
Function: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. similarity: Belongs to the interleukin-1 receptor family. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 1 TIR domain. subunit: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. tissue specificity: Mainly expressed in epithelial tissues such as kidney, lung and gut.
UniProt
Q6IA17
Swiss Prot
Q6IA17
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
SIGIR
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
45kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
45kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type III membrane protein .
Gene ID (Human)
59307

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