MUL1 rabbit pAb

MUL1 rabbit pAb

• Description: Domain: The zinc finger domain is required for E3 ligase activity. function: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 RING-type zinc finger. subcellular location: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. subunit: Homooligomer. Interacts with MAP3K7/TAK1. tissue specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.
• Gene ID: 79594
• UniProt: Q969V5
• Cellular Locus: Mitochondrion outer membrane ; Multi-pass membrane protein. Peroxisome. Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome..
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthesized peptide derived from part region of human protein
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 38kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.