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JAML1 rabbit pAb

CAT: 0855-ES10721-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10721-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:The Ig-like V-type domain 2 mediates interaction with CXADR., function:May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells., induction:Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells., similarity:Belongs to the immunoglobulin superfamily., similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains., subcellular location:Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN., subunit:Interacts with CXADR., tissue specificity:Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.
Description
Domain: The Ig-like V-type domain 2 mediates interaction with CXADR. function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. similarity: Belongs to the immunoglobulin superfamily. similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains. subcellular location: Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. subunit: Interacts with CXADR. tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.
UniProt
Q86YT9
Swiss Prot
Q86YT9
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
JAML1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
43kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell junction . Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515) .
Gene ID (Human)
120425

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