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HIPK3 rabbit pAb

CAT: 0855-ES10650-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10650-01Size:50 µL
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors., PTM:Autophosphorylated, but autophosphorylation is not required for catalytic activity., PTM:May be sumoylated., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily., similarity:Contains 1 protein kinase domain., subunit:Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity) . Interacts with UBL1/SUMO-1., tissue specificity:Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. function: Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity. PTM: May be sumoylated. similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. similarity: Contains 1 protein kinase domain. subunit: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1. tissue specificity: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
UniProt
Q9H422
Swiss Prot
Q9H422
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 770-850
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
133kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
133kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus .
Gene ID (Human)
10114

UniProtKB · Q9H422

Homeodomain-interacting protein kinase 3

HIPK3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9H422
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HIPK3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
O14632, Q2PBG4, Q2PBG5, Q92632, Q9HAS2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

CytoplasmNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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