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WWTR1 rabbit pAb

CAT: 0855-ES10647-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10647-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:Binds to transcription factors via its WW domain., domain:The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes., function:Functions as a transcriptional coactivator., PTM:Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export., similarity:Contains 1 WW domain., subcellular location:Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ., subunit:Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP., tissue specificity:Highly expressed in kidney, heart, placenta and lung.
Description
Domain: Binds to transcription factors via its WW domain. Domain: The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes. function: Functions as a transcriptional coactivator. PTM: Phosphorylated. Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. similarity: Contains 1 WW domain. subcellular location: Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. subunit: Binds to SLC9A3R2 via the PDZ motif at the plasma membrane. Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP. tissue specificity: Highly expressed in kidney, heart, placenta and lung.
UniProt
Q9GZV5
Swiss Prot
Q9GZV5
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
WWTR1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
44kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
44kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Cell membrane . Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies (By similarity) . When phosphorylated, is retained in the cytoplasm by YWHAZ (By similarity) . Can be retained in the nucleus by MED15 (PubMed:18568018) . Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499) . At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity) . .
Gene ID (Human)
25937

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