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TRRAP rabbit pAb

CAT: 0855-ES10388-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10388-02Size:100 µL
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Background
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Description
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011],
UniProt
Q9Y4A5
Swiss Prot
Q9Y4A5
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Target
TRRAP
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
424kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
424kD
Fragment
IgG
Subcellular Location
Nucleus .
Gene ID (Human)
8295

UniProtKB · Q9Y4A5

Transformation/transcription domain-associated protein

TRRAP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y4A5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TRRAP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A4D265, O75218, Q9Y631, Q9Y6H4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorChromatin regulator

Coding sequence diversity

Alternative splicing

Disease

Autism spectrum disorderDeafnessDisease variantIntellectual disabilityNon-syndromic deafness

Cellular component

Nucleus

Biological process

TranscriptionTranscription regulation

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