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SGMR1 rabbit pAb

CAT: 0855-ES10259-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
Description
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013],
UniProt
Q99720
Swiss Prot
Q99720
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 90-170
Target
SGMR1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
24kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
24kD
Fragment
IgG
Subcellular Location
Nucleus inner membrane . Nucleus outer membrane . Nucleus envelope . Cytoplasmic vesicle . Endoplasmic reticulum membrane . Membrane ; Single-pass membrane protein . Lipid droplet . Cell junction. Cell membrane . Cell projection, growth cone. Cell junction, synapse, postsynaptic density membrane . During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (PubMed:10406945) . Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum. Accumulation at the endoplasmic reticulum is prominent in alpha-motor neurons of patients with amyotrophic lateral sclerosis (PubMed:23314020) . Enriched at cell-cell communication regions, growth cone and postsynaptic structu
Gene ID (Human)
10280

UniProtKB · Q99720

Sigma non-opioid intracellular receptor 1

SGMR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99720
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SIGMAR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DRM7, O00673, O00725, Q0Z9W6, Q153Z1, Q2TSD1, Q53GN2, Q7Z653, Q8N7H3, Q9NYX0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegenerationNeuropathy

Cellular component

Cell junctionCell membraneCell projectionCytoplasmic vesicleEndoplasmic reticulumLipid dropletMembraneNucleusPostsynaptic cell membraneSynapse

Biological process

Lipid transportTransport

Molecular function

Receptor

Domain

TransmembraneTransmembrane helix

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