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NLK rabbit pAb

CAT: 0855-ES10199-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10199-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Activated by tyrosine and threonine phosphorylation (By similarity) . Activated by activin., function:Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity) . Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3., PTM:Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme., similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily., similarity:Contains 1 protein kinase domain., subcellular location:Predominantly nuclear. A smaller fraction is cytoplasmic., subunit:Interacts with STAT3 (By similarity) . Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by tyrosine and threonine phosphorylation (By similarity). Activated by activin. function: Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3. PTM: Dually phosphorylated on Thr-291 and Tyr-293, which activates the enzyme. similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. similarity: Contains 1 protein kinase domain. subcellular location: Predominantly nuclear. A smaller fraction is cytoplasmic. subunit: Interacts with STAT3 (By similarity). Interacts with RNF138/NARF and TCF7L2/TCF4. Interacts with HIPK2 and MYB.
UniProt
Q9UBE8
Swiss Prot
Q9UBE8
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 230-310
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
57kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
57kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity) . .
Gene ID (Human)
51701

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