BD1L1 rabbit pAb

• Background:

  Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM.

• Description:

  Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM.

• Gene ID:

  259282

• UniProt:

  Q8NFC6

• Cellular Locus:

  Chromosome. Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 1280-1360

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  IHC, IF

• Validated Applications:

  IHC, IF

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  IHC-p 1:50-300

• Molecular Weight:

  335kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  335 kD

• Subcellular Location:

  Chromosome . Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection. .

• Gene ID (Human):

  259282

• SwissProt (Human):

  Q8NFC6