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UNC5D rabbit pAb

CAT: 0855-ES9893-01Size: 50 µLDry Ice: NoHazardous: No
CAT#: ES9893-01Size: 50 µL
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand., PTM:Phosphorylated on cytoplasmic tyrosine residues., PTM:Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis., similarity:Belongs to the unc-5 family., similarity:Contains 1 death domain., similarity:Contains 1 Ig-like (immunoglobulin-like) domain., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 ZU5 domain., similarity:Contains 2 TSP type-1 domains., subunit:Interacts with the cytoplasmic part of DCC.
Description
Function: Receptor for netrin. May be involved in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. PTM: Phosphorylated on cytoplasmic tyrosine residues. PTM: Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. similarity: Belongs to the unc-5 family. similarity: Contains 1 death domain. similarity: Contains 1 Ig-like (immunoglobulin-like) domain. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 1 ZU5 domain. similarity: Contains 2 TSP type-1 domains. subunit: Interacts with the cytoplasmic part of DCC.
UniProt
Q6UXZ4
Swiss Prot
Q6UXZ4
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 160-240
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
104kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
104kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Gene ID (Human)
137970

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