NDUS2 rabbit pAb

CAT: 0855-ES9878-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES9878-02Size:100 µL

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Background

The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I) . Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Description

The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],

UniProt

O75306

Swiss Prot

O75306

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from human protein . at AA range: 160-240

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight

50kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

50kD

Fragment

IgG

Subcellular Location

Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

Gene ID (Human)

4720

UniProtKB · O75306

NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

NDUS2_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O75306
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NDUFS2
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 7.1.1.2
Processing: Precursor
Secondary accessions: D3DVG7, J3KPM7, Q5VTW0, Q969P3, Q9UEV3

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SIronIron-sulfurMetal-bindingNADUbiquinone

PTM

AcetylationMethylation

Coding sequence diversity

Alternative splicing

Disease

Disease variantLeber hereditary optic neuropathyPrimary mitochondrial disease

Biological process

Electron transportRespiratory chainTransport

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Molecular function

OxidoreductaseTranslocase

Domain

Transit peptide

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Alternative Products

Catalog	Name
MBS9515687-01	NDUS2 Rabbit Polyclonal Antibody
PAV2490	Rabbit Anti-NDUS2/NDUFS2 Polyclonal Antibody
C44956-01	NDUS2 Antibody
539515-01	NDUS2 discontinued
BT-AP11781-01	NDUS2 Polyclonal Antibody
STJ191036	Anti-NDUS2 antibody
WP1356-01	U-Blot® NDUS2 Polyclonal Antibody
RTR125	Rabbit-to-Rabbit Blocking Reagent
NBP1-71681	Rabbit Normal Rabbit Serum
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