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MUC4 rabbit pAb

CAT: 0855-ES9825-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9825-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
Description
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008],
UniProt
Q99102
Swiss Prot
Q99102
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 1970-2050
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
238kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
238kD
Fragment
IgG
Subcellular Location
[Mucin-4 beta chain]: Cell membrane ; Single-pass membrane protein . Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. .; [Mucin-4 alpha chain]: Cell membrane . Secreted . Forms a complex with Mucin-4 beta chain at the cell membrane. .; [Isoform 3]: Cell membrane ; Single-pass membrane protein .; [Isoform 11]: Secreted .; [Isoform 15]: Secreted .; [Isoform 17]: Cell membrane ; Single-pass membrane protein .
Gene ID (Human)
4585

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