MUC4 rabbit pAb

MUC4 rabbit pAb

• Description: The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008],
• Gene ID: 4585
• UniProt: Q99102
• Cellular Locus: [Mucin-4 beta chain]: Cell membrane ; Single-pass membrane protein. Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing..; [Mucin-4 alpha chain]: Cell membrane. Secreted. Forms a complex with Mucin-4 beta chain at the cell membrane..; [Isoform 3]: Cell membrane ; Single-pass membrane protein.; [Isoform 11]: Secreted.; [Isoform 15]: Secreted.; [Isoform 17]: Cell membrane ; Single-pass membrane protein.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized peptide derived from human protein . at AA range: 1970-2050
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 238kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.