LRBA rabbit pAb

• Background :

  The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS) . The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

• Description :

  The protein encoded by this gene is a member of the WDL-BEACH-WD (WBW) gene family. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). The encoded protein associates with protein kinase A and may be involved in leading intracellular vesicles to activated receptor complexes, which aids in the secretion and/or membrane deposition of immune effector molecules. Defects in this gene are associated with the disorder common variable immunodeficiency-8 with autoimmunity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012],

• UniProt :

  P50851

• Swiss Prot :

  P50851

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 1970-2050

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p 1:50-300

• Molecular Weight :

  314kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  314kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein .

• Gene ID (Human) :

  987