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LRSM1 rabbit pAb

CAT: 0855-ES9626-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9626-01Size:50 µL
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Background
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]
Description
This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012],
UniProt
Q6UWE0
Swiss Prot
Q6UWE0
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
79kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
79kD
Fragment
IgG
Subcellular Location
Cytoplasm . Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501) . Localizes to intracellular bacterial pathogens (PubMed:23245322) . .
Gene ID (Human)
90678

UniProtKB · Q6UWE0

E3 ubiquitin-protein ligase LRSAM1

LRSM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6UWE0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LRSAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AutophagyProtein transportTransportUbl conjugation pathway

Disease

Charcot-Marie-Tooth diseaseDisease variantNeurodegenerationNeuropathy

Domain

Coiled coilLeucine-rich repeatRepeatZinc-finger

Cellular component

Cytoplasm

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

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