AGRIN rabbit pAb

• Background :

  This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

• Description :

  This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015],

• UniProt :

  O00468

• Swiss Prot :

  O00468

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 1900-1980

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  224kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  224kD

• Fragment :

  IgG

• Subcellular Location :

  [Isoform 1]: Secreted, extracellular space, extracellular matrix . Synaptic basal lamina at the neuromuscular junction. .; [Isoform 2]: Cell junction, synapse . Cell membrane ; Single-pass type II membrane protein .

• Gene ID (Human) :

  375790