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ERCC2 rabbit pAb

CAT: 0855-ES9271-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9271-02Size:100 µL
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Background
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Description
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
UniProt
P18074
Swiss Prot
P18074
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 220-300
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
83kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
83kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm, cytoskeleton, spindle .
Gene ID (Human)
2068

UniProtKB · P18074

General transcription and DNA repair factor IIH helicase subunit XPD

ERCC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18074
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERCC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
TFIIH subunit XPD
EC number
5.6.2.3
Processing
—
Secondary accessions
Q2TB78, Q2YDY2, Q7KZU6, Q8N721
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

4Fe-4SATP-bindingIronIron-sulfurMagnesiumMetal-bindingNucleotide-binding

Coding sequence diversity

Alternative splicing

Disease

CataractCockayne syndromeDeafnessDisease variantDwarfismIchthyosisXeroderma pigmentosum

Biological process

Chromosome partitionDNA damageDNA repairHost-virus interactionTranscriptionTranscription regulation

Cellular component

CytoplasmCytoskeletonNucleus

Molecular function

DNA-bindingHelicaseHydrolaseIsomerase

PTM

Ubl conjugation

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