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CDA7L rabbit pAb

CAT: 0855-ES9119-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9119-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1., induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line., miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation., subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction., subunit:Interacts with MYC and PSIP1., tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.
Description
Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. induction: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. miscellaneous: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. subcellular location: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. subunit: Interacts with MYC and PSIP1. tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.
UniProt
Q96GN5
Swiss Prot
Q96GN5
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 140-220
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
49kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
49kD
Fragment
IgG
Subcellular Location
Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.
Gene ID (Human)
55536

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