CDA7L rabbit pAb

• Background :

  Function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1., induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line., miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation., subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction., subunit:Interacts with MYC and PSIP1., tissue specificity:Ubiquitous. Overexpressed in medulloblastoma.

• Description :

  Function: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. induction: By MYC overexpression in a concentration dependent manner in neuroblastoma cell line. miscellaneous: Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation. subcellular location: Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. subunit: Interacts with MYC and PSIP1. tissue specificity: Ubiquitous. Overexpressed in medulloblastoma.

• UniProt :

  Q96GN5

• Swiss Prot :

  Q96GN5

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 140-220

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  49kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  49kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.

• Gene ID (Human) :

  55536