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HASP rabbit pAb

CAT: 0855-ES9078-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9078-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., function:Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis., PTM:Autophosphorylated on both serine and threonine residues (By similarity) . Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily., similarity:Contains 1 protein kinase domain., tissue specificity:Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
Description
Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. function: Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis. PTM: Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. similarity: Contains 1 protein kinase domain. tissue specificity: Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
UniProt
Q8TF76
Swiss Prot
Q8TF76
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 270-350
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
87kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
87kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Cytoplasm, cytoskeleton, spindle . Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
Gene ID (Human)
83903

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