CD275 rabbit pAb

CAT: 0855-ES8796-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES8796-01Size:50 µL
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Background
Alternative products:Additional isoforms seem to exist, function:Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function., induction:Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells., sequence caution:The sequence differs from that shown in position 300 onward for unknown reason., sequence caution:Translation N-terminally shortened., similarity:Belongs to the immunoglobulin superfamily. BTN/MOG family., similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain., similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain., tissue specificity:Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
Description
Alternative products: Additional isoforms seem to exist, function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and Cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. induction: Constitutive expression is further enhanced by treatment with TNF-alpha in peripheral blood B-cells and monocytes, while it is decreased in dendritic cells. sequence Caution: The sequence differs from that shown in position 300 onward for unknown reason. sequence Caution: Translation N-terminally shortened. similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. tissue specificity: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells.
UniProt
O75144
Swiss Prot
O75144
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 201-250
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
ICOS ligand (B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD antigen CD275)
Gene ID (Human)
23308

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