CD274 rabbit pAb

CAT: 0855-ES8791-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES8791-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Description
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and Cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Product Name Alternative
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
UniProt
Q9NZQ7
Swiss Prot
Q9NZQ7
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 181-230
Target
CD274
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000 IF 1:100-300 Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Associates with CMTM6 at recycling endosomes, where it is protected from being targeted for lysosomal degradation. .; [Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Endomembrane system ; Single-pass type I membrane protein .
Other Product Names
Programmed cell death 1 ligand 1 (PD-L1) (PDCD1 ligand 1) (Programmed death ligand 1) (B7 homolog 1) (B7-H1) (CD antigen CD274)
Gene ID (Human)
29126

Related Products

CatalogName
ES1902-01CD284 rabbit pAb
ES8700-01CD204 rabbit pAb
ES7878-01CD264 rabbit pAb
ES4345-01CD244 rabbit pAb
ES8796-01CD275 rabbit pAb
ES4911-01CD272 rabbit pAb
ES4135-01CD294 rabbit pAb
ES4015-01CD276 rabbit pAb
ES8785-01CD24 rabbit pAb
ES10514-01CD27 rabbit pAb

Alternative Products

CatalogName
MBS8540629-01CD274 Rabbit pAb
A27937-01CD274 Rabbit mAb
E46F1900CD274 Rabbit Monoclonal Antibody
E38MA4152Recombinant CD274 Rabbit mAb
DL92825A-01Rabbit anti-CD274 Antibody
E10G13754CD274 Rabbit Polyclonal Antibody
APR29033N-01CD274 Rabbit pAb (APR29033N)
MBS224074-01RABBIT ANTI HUMAN CD274

Popular Products