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CD236 rabbit pAb

CAT: 0855-ES8704-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8704-02Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Description
Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012],
UniProt
P04921
Swiss Prot
P04921
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 11-60
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, ELISA 1:10000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type III membrane protein. Linked to the membrane via band 4.1.
Other Product Names
Glycophorin-C (Glycoconnectin; Glycophorin-D; GPD; Glycoprotein beta; PAS-2'; Sialoglycoprotein D; CD antigen CD236)
Gene ID (Human)
2995

UniProtKB · P04921

Glycophorin-C

GLPC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04921
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GYPC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R522, Q53SV9, Q92642
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Blood group antigen

Cellular component

Cell membraneMembrane

PTM

GlycoproteinPhosphoprotein

Ligand

Sialic acid

Domain

TransmembraneTransmembrane helix

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