Tcl1 rabbit pAb

• Background:

  Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]) .[supplied by OMIM, Jul 2010]

• Description:

  Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al. 2000 [PubMed 10983986]). [supplied by OMIM, Jul 2010],

• Synonyms:

  T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)

• Gene ID:

  8115

• UniProt:

  P56279

• Cellular Locus:

  Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthetic peptide from human protein at AA range: 30-110

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Validated Applications:

  WB, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight:

  13kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  13kD

• Subcellular Location:

  Cytoplasm . Nucleus . Microsome . Endoplasmic reticulum . Microsomal fraction.

• Other Product Names:

  T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)

• Gene ID (Human):

  8115

• SwissProt (Human):

  P56279