Tcl1 rabbit pAb

CAT: 0855-ES8608-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES8608-01Size:50 µL
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Background
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR) -alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]) . In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]) .[supplied by OMIM, Jul 2010]
Description
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al. 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al. 2000 [PubMed 10983986]). [supplied by OMIM, Jul 2010],
Product Name Alternative
T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
UniProt
P56279
Swiss Prot
P56279
Reactivity
Human; Rat; Mouse
Immunogen
Synthetic peptide from human protein at AA range: 30-110
Target
Tcl1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
13kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
13kD
Fragment
IgG
Subcellular Location
Cytoplasm . Nucleus . Microsome . Endoplasmic reticulum . Microsomal fraction.
Other Product Names
T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1)
Gene ID (Human)
8115

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